Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | GLP1R | P43220 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5328430 | 0.77 | AURKA (0.55) | KDRAURKANR1H2GHSRBRD4 | |
| SCHEMBL5330620 | 0.73 | BRD4 (0.55) | NR1H2BRD4CREBBP | |
| SCHEMBL5334220 | 0.70 | AURKA (0.46) | KDRAURKANR1H2GHSRBRD4 | |
| SCHEMBL3047240 | 0.70 | CCNB2 (0.40) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL5327530 | 0.69 | AURKA (0.48) | KDRAURKACDK1NR1H2BRD4 | |
| SCHEMBL5331753 | 0.67 | AURKA (0.42) | KDRAURKACDK1PARP1MAPK1 | |
| SCHEMBL5331995 | 0.66 | AURKA (0.42) | KDRAURKANR1H2GHSRBRD4 | |
| SCHEMBL5333314 | 0.66 | KDR (0.52) | KDRAURKANR1H2BRD4CREBBP | |
| SCHEMBL3840883 | 0.66 | PARP1 (0.36) | PARP1NR1H2BRD4CREBBP | |
| SCHEMBL5334755 | 0.66 | KDR (0.40) | KDRAURKACDK1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007047646-A2 | SUBSTITUTED DIHYDRO-ISOINDOLONES USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-04-26 | — | — | WO | disclosed |