Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13995595 | 0.76 | BACE1 (0.52) | BACE1KDM4E | |
| SCHEMBL4149124 | 0.75 | BACE1 (0.76) | BACE1KDM4E | |
| SCHEMBL6403829 | 0.74 | BACE1 (0.49) | BACE1KDM4E | |
| SCHEMBL4142484 | 0.74 | BACE1 (1.00) | BACE1KDM4E | |
| SCHEMBL27370401 | 0.72 | BACE1 (0.47) | BACE1KDM4EALDH1A1 | |
| SCHEMBL13711084 | 0.72 | BACE1 (0.62) | BACE1KDM4E | |
| SCHEMBL4141182 | 0.72 | BACE1 (0.74) | BACE1 | |
| SCHEMBL4148180 | 0.72 | BACE1 (0.74) | BACE1KDM4E | |
| SCHEMBL5662165 | 0.71 | BACE1 (0.46) | BACE1KDM4E | |
| SCHEMBL4149271 | 0.71 | BACE1 (0.60) | BACE1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802587-A1 | SUBSTITUTED AMINO-COMPOUNDS AND USES THEREOF | AstraZeneca AB (SE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006041404-A1 | SUBSTITUTED AMINO-COMPOUNDS AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |