Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 15/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25575726 | 0.80 | CDK9 (0.41) | BACE1SCN5ASCN9ABRPF1 | |
| SCHEMBL27370401 | 0.80 | BACE1 (0.47) | BACE1KDM4E | |
| SCHEMBL24879507 | 0.78 | SCN5A (0.40) | BACE1SCN5ASCN9ABRPF1 | |
| SCHEMBL5662165 | 0.78 | BACE1 (0.46) | BACE1KDM4E | |
| SCHEMBL5663091 | 0.75 | BACE1 (0.44) | BACE1KDM4E | |
| SCHEMBL9409123 | 0.75 | SCN5A (0.51) | BACE1KDM4ESCN5ASCN9ABRPF1 | |
| SCHEMBL9300556 | 0.75 | MAPT (0.39) | BACE1SCN5ASCN9ABRPF1 | |
| SCHEMBL5334890 | 0.74 | BACE1 (0.58) | BACE1KDM4E | |
| SCHEMBL6542445 | 0.73 | CLK4 (0.34) | BACE1KDM4E | |
| SCHEMBL15427623 | 0.72 | BACE1 (0.51) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406911-B1 | 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 2016-01-06 | — | — | EP | disclosed |
| US-20050038058-A1 | Novel compounds and methods for therapy | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY | 2005-02-17 | — | — | US | disclosed |
| US-6818633-B2 | Antiviral for RNA or DNA viruses such as HIV, HBV or HSV; acyclic pyrimidine nucleoside phosphonate analogues; 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidine; ; alkylating the 6-hydroxypyrimidine base with a dialkyl 2-chloroethoxymethylphosphonate | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2004-11-16 | — | — | US | disclosed |
| EP-1406911-A1 | 6-[2-(PHOSPHONOMETHOXY)ALKOXY]PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2004-04-14 | — | — | EP | disclosed |
| US-20030109499-A1 | Novel compounds and methods for therapy | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ACADEMY OF SCIENCES | 2003-06-12 | — | — | US | disclosed |
| WO-2003002580-A1 | 6-`2-(PHOSPHONOMETHOXY)ALKOXY PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OFTHE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038058-A1 | Novel compounds and methods for therapy | ZC3HAV1, IFNAR1, EIF2AK2 | BACE1 1657/4885KDM4E 2022/4885SCN5A 4845/4885 |
| US-20030109499-A1 | Novel compounds and methods for therapy | IFNAR1, ZC3HAV1, EIF2AK2 | BACE1 1102/4885KDM4E 2756/4885SCN5A 4770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.