Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5334678 | 1.00 | REN (0.43) | RENCYP3A4LIPEPDE4BTACR1 | |
| SCHEMBL5338393 | 0.91 | REN (0.45) | RENCYP3A4LIPEPDE4BTACR1 | |
| SCHEMBL5334681 | 0.84 | REN (0.42) | RENCYP3A4PDE4B | |
| SCHEMBL5942264 | 0.76 | REN (0.47) | RENCYP3A4 | |
| SCHEMBL3088604 | 0.75 | REN (0.40) | RENCYP3A4TACR1JAK2JAK1 | |
| SCHEMBL5338396 | 0.74 | REN (0.43) | RENCYP3A4PDE4B | |
| SCHEMBL5331903 | 0.71 | REN (0.64) | RENCYP3A4 | |
| SCHEMBL5330602 | 0.71 | REN (0.64) | RENCYP3A4 | |
| SCHEMBL10183732 | 0.71 | REN (0.49) | RENCYP3A4PDE4BTACR1JAK2 | |
| SCHEMBL6112238 | 0.70 | REN (0.49) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007049224-A1 | NOVEL HEXAHYDRO- OR OCTAHYDRO-CYCLOPENTA[C]PYRROLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2007-05-03 | — | — | WO | disclosed |