Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 15/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11820336 | 0.84 | SLC6A2 (0.48) | GAAMAPTTP53RECQLSLC6A2 | |
| SCHEMBL5422791 | 0.84 | MAPT (0.47) | GAAMAPTTP53RECQLSLC6A2 | |
| SCHEMBL30368131 | 0.84 | SLC6A2 (0.49) | GAAMAPTTP53RECQLSLC6A2 | |
| SCHEMBL14833300 | 0.81 | PDE4A (0.47) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL734590 | 0.81 | PDE4A (0.47) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL11823533 | 0.80 | GAA (0.43) | GAAMAPTTP53RECQLSLC6A2 | |
| SCHEMBL30368451 | 0.80 | ALDH1A1 (0.46) | GAAMAPTTP53RECQL | |
| SCHEMBL14529789 | 0.80 | MAPT (0.43) | GAAMAPTTP53RECQLSLC6A2 | |
| SCHEMBL657183 | 0.79 | SLC6A2 (0.44) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL10672428 | 0.79 | MAPT (0.77) | GAAMAPTTP53RECQLCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| WO-2007051062-A2 | SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
| WO-2007051062-A2 | SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
| EP-0036718-B1 | 7-CHLORO-3-SUBSTITUTED ARYL-3,4-DIHYDRO-1,9(2H,10H) AND 10-HYDROXY ACRIDINEDIONEIMINES, PROCESSES FOR PRODUCING THE ACRIDINEDIONEIMINES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE ACRIDINEDIONEIMINES | WARNER-LAMBERT COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |
| EP-0036718-A2 | 7-Chloro-3-substituted aryl-3,4-dihydro-1,9(2H,10H) and 10-hydroxy acridinedioneimines, processes for producing the acridinedioneimines, and pharmaceutical compositions containing the acridinedioneimines | WARNER-LAMBERT COMPANY (US) | 1981-09-30 | — | — | EP | disclosed |
| US-4291034-A | 7-Chloro-3-substituted aryl-3,4-dihydro-1,9(2H,10H) and 10 hydroxy acridinedioneimines having antimalarial activity | WARNER LAMBERT COMPANY (US) | 1981-09-22 | — | — | US | disclosed |
| US-3947449-A | Tetrahydroacridones having chemotherapeutic action and process for preparing them | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | C3AR1, C5AR1, C5AR2 | GAA 3421/4885MAPT 4656/4885TP53 3218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.