Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 3/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14467035 | 0.89 | MAPK14 (0.47) | MAPK14CYP2C9CYP2C19HTR2BMEN1 | |
| SCHEMBL5346573 | 0.82 | AURKA (0.49) | MAPK14CYP2C9CYP2C19HTR2BCCR3 | |
| SCHEMBL5339899 | 0.78 | MAPK14 (0.47) | MAPK14CYP2C9CYP2C19HTR2BMEN1 | |
| SCHEMBL14466890 | 0.78 | MAPK14 (0.45) | MAPK14CYP2C9CYP2C19HTR2BCCR3 | |
| SCHEMBL14467011 | 0.78 | MAPK14 (0.48) | MAPK14CYP2C9CYP2C19HTR2BMEN1 | |
| SCHEMBL5323872 | 0.77 | MAPK14 (0.54) | MAPK14CYP2C9CYP2C19HTR2BMEN1 | |
| SCHEMBL5319166 | 0.76 | MAPK14 (0.57) | MAPK14CYP2C9CYP2C19HTR2B | |
| SCHEMBL5323974 | 0.76 | MAPK14 (0.57) | MAPK14CYP2C9CYP2C19HTR2BCCR3 | |
| SCHEMBL14467025 | 0.76 | MAPK14 (0.60) | MAPK14CYP2C9CYP2C19HTR2BCCR3 | |
| Hydrochloric Acid SCHEMBL5321355 | 0.75 | MAPK14 (0.56) | MAPK14CYP2C9CYP2C19HTR2BCCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007082079-A2 | PIPERIDINE AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-19 | — | — | WO | disclosed |
| WO-2007082079-A2 | PIPERIDINE AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-19 | — | — | WO | disclosed |