SCHEMBL533609

SCHEMBL533609

O=c1ccn([C@H]2CC[C@@H](COP(=O)(O)O)O2)c(=O)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DUT P33316 2/20 0.53
P2RY6 Q15077 8/20 0.48
P2RY2 P41231 11/20 0.47
P2RY4 P51582 6/20 0.47
P2RY14 Q15391 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29264470 1.00 DUT (0.53) DUTP2RY6P2RY2P2RY4P2RY14
SCHEMBL20879422 1.00 DUT (0.53) DUTP2RY6P2RY2P2RY4P2RY14
SCHEMBL9279845 0.91 P2RY6 (0.58) DUTP2RY6P2RY2P2RY4P2RY14
SCHEMBL6913590 0.89 DUT (0.47) DUTP2RY6P2RY2P2RY4P2RY14
SCHEMBL1501001 0.89 P2RY2 (0.61) P2RY6P2RY2P2RY4P2RY14
SCHEMBL22110865 0.89 P2RY2 (0.61) P2RY6P2RY2P2RY4P2RY14
SCHEMBL661070 0.89 P2RY2 (0.61) P2RY6P2RY2P2RY4P2RY14
SCHEMBL25711998 0.89 P2RY2 (0.61) P2RY6P2RY2P2RY4P2RY14
SCHEMBL14731558 0.89 P2RY2 (0.55) DUTP2RY6P2RY2P2RY4P2RY14
SCHEMBL5320623 0.88 P2RY6 (0.49) DUTP2RY6P2RY2P2RY4P2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 199 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12383558-B2 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections EMORY UNIVERSITY (US) 2025-08-12 US disclosed
EP-4556010-A2 JAK INHIBITORS FOR USE IN THE PREVENTION OR TREATMENT OF A VIRAL DISEASE CAUSED BY A CORONAVIRIDAE Emory University (US) 2025-05-21 EP disclosed
EP-3750544-B1 JAK INHIBITORS FOR USE IN THE PREVENTION OR TREATMENT OF A VIRAL DISEASE CAUSED BY A CORONAVIRIDAE UNIV EMORY (US) 2025-03-05 EP disclosed
US-20240415838-A1 USE OF TREM-1 INHIBITORS FOR TREATMENT, ELIMINATION AND ERADICATION OF HIV-1 INFECTION UNIV EMORY (US) 2024-12-19 US disclosed
US-20240262857-A1 NOVEL UNIVERSAL ANTI-RNA VIRUS AGENTS EMORY UNIVERSITY 2024-08-08 US disclosed
US-20240209428-A1 Pyrophosphorolysis activated fluorescence to measure PAP amplification of nucleic acid DING SHAOFENG (US) 2024-06-27 US disclosed
US-20240173322-A1 ANTIVIRAL JAK INHIBITORS USEFUL IN TREATING OR PREVENTING RETROVIRAL AND OTHER VIRAL INFECTIONS UNIV EMORY (US) 2024-05-30 US disclosed
US-11969427-B2 Use of TREM-1 inhibitors for treatment, elimination and eradication of HIV-1 infection EMORY UNIVERSITY (US) 2024-04-30 US disclosed
US-11921049-B2 Pyrophosphorolysis activated fluorescence to measure PAP amplification of nucleic acid DING SHAOFENG (US) 2024-03-05 US disclosed
US-11744831-B2 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections EMORY UNIVERSITY (US) 2023-09-05 US disclosed
WO-2000043014-A2 BETA-D-2',3'-DIDEHYDRO-2',3'-DIDEOXY-5-FLUOROCYTIDINE FOR USE IN THE TREATMENT OF HIV INFECTIONS EMORY UNIVERSITY (US) 2000-07-27 WO disclosed
US-6071922-A PYRIMIDINE-BASE NUCLEOSIDES; VIRICIDES; HIV; HEPATITIS B VIRUS; AIDS-RELATED COMPLEX; IMMUNODEFICIENCY VIRUS IN ANIMALS AND HUMANS; ANTIPROLIFERATIVE AGENTS EMORY UNIVERSITY (US) 2000-06-06 US disclosed
WO-1999066936-A9 USE OF 3'-AZIDO-2',3'-DIDEOXYURIDINE IN COMBINATION WITH FURTHER ANTI-HIV DRUGS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF HIV UNIV EMORY (US) 2000-04-06 WO disclosed
EP-0986375-A2 USE OF MKC-442 IN COMBINATION WITH OTHER ANTIVIRAL AGENTS Triangle Pharmaceuticals Inc. (US) 2000-03-22 EP disclosed
EP-0970078-A1 SYNTHESIS, ANTI-HUMAN IMMUNODEFICIENCY VIRUS AND ANTI-HEPATITIS B VIRUS ACTIVITIES OF 1,3-OXASELENOLANE NUCLEOSIDES EMORY UNIVERSITY (US) 2000-01-12 EP disclosed
WO-1999066936-A1 USE OF 3'-AZIDO-2',3'-DIDEOXYURIDINE IN COMBINATION WITH FURTHER ANTI-HIV DRUGS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF HIV EMORY UNIVERSITY (US) 1999-12-29 WO disclosed
WO-1999043691-A1 2'-FLUORONUCLEOSIDES EMORY UNIVERSITY (US) 1999-09-02 WO disclosed
WO-1998041522-A9 SYNTHESIS, ANTI-HUMAN IMMUNODEFICIENCY VIRUS AND ANTI-HEPATITIS B VIRUS ACTIVITIES OF 1,3-OXASELENOLANE NUCLEOSIDES 1999-03-04 WO disclosed
WO-1998044913-A2 COMPOSITIONS CONTAINING MKC-442 IN COMBINATION WITH OTHER ANTIVIRAL AGENTS TRIANGLE PHARMACEUTICALS, INC. (US) 1998-10-15 WO disclosed
WO-1998041522-A1 SYNTHESIS, ANTI-HUMAN IMMUNODEFICIENCY VIRUS AND ANTI-HEPATITIS B VIRUS ACTIVITIES OF 1,3-OXASELENOLANE NUCLEOSIDES EMORY UNIVERSITY (US) 1998-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11744831-B2 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections JAK1, JAK3, PNP DUT 36/4885P2RY6 736/4885P2RY2 776/4885
US-20240415838-A1 USE OF TREM-1 INHIBITORS FOR TREATMENT, ELIMINATION AND ERADICATION OF HIV-1 INFECTION MERTK, PNP, HAVCR2 DUT 123/4885P2RY6 104/4885P2RY2 143/4885
US-11969427-B2 Use of TREM-1 inhibitors for treatment, elimination and eradication of HIV-1 infection MERTK, PNP, HAVCR2 DUT 123/4885P2RY6 104/4885P2RY2 143/4885
US-20240262857-A1 NOVEL UNIVERSAL ANTI-RNA VIRUS AGENTS NSUN2, RBM28, HNRNPC DUT 120/4885P2RY6 3462/4885P2RY2 3773/4885
US-20240173322-A1 ANTIVIRAL JAK INHIBITORS USEFUL IN TREATING OR PREVENTING RETROVIRAL AND OTHER VIRAL INFECTIONS JAK1, JAK3, PNP DUT 35/4885P2RY6 689/4885P2RY2 880/4885
US-12383558-B2 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections JAK1, JAK3, PNP DUT 35/4885P2RY6 689/4885P2RY2 880/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.