SCHEMBL5336264

SCHEMBL5336264

NS(=O)(=O)c1ccc2c(c1)C=CCO2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STS P08842 1/20 0.50
CA2 P00918 9/20 0.44
CA9 Q16790 6/20 0.44
CA12 O43570 5/20 0.44
CA1 P00915 8/20 0.42
CA7 P43166 4/20 0.42
CA14 Q9ULX7 3/20 0.42
CYP2B6 P20813 1/20 0.41
PTGS1 P23219 3/20 0.39
PTGS2 P35354 3/20 0.39
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.38
ADRA2A P08913 1/20 0.37
PNMT P11086 1/20 0.37
ADRA2B P18089 1/20 0.37
ADRA2C P18825 1/20 0.37
CA4 P22748 2/20 0.37
CA5A P35218 2/20 0.37
CA5B Q9Y2D0 2/20 0.37
LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31700562 1.00 STS (0.50) STSCA2CA9CA12CA1
SCHEMBL28232625 0.87 STS (0.61) STSCA2CA9CA12CA1
SCHEMBL12988638 0.84 CA2 (0.40) STSCA2CA9CA12CA1
SCHEMBL27798617 0.83 STS (0.43) STSCA2CA9CA12CA1
SCHEMBL4739311 0.83 STS (0.43) STSCA2CA9CA12CA1
SCHEMBL11506043 0.83 STS (0.43) STSCA2CA9CA12CA1
SCHEMBL12988457 0.75 CA2 (0.46) STSCA2CA9CA12CA1
SCHEMBL12989492 0.75 CA2 (0.46) STSCA2CA9CA12CA1
SCHEMBL4483680 0.73 PHGDH (0.38) STSCYP2B6RAB9ANPC1LMNA
SCHEMBL6957005 0.73 CA1 (0.44) STSCA2CA9CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105705489-B Compound as immunomodulator 百时美施贵宝公司 2019-04-26 CN claimed
CN-108884093-A 6,7,8,9- tetrahydro -5H- pyrido [2,3-d] azepine * dopamine D 3 ligands 辉瑞公司 2018-11-23 CN claimed
CN-108383828-A 1 new, 2- as chemokine receptor modulators is bis--sulfamide derivative 阿勒根公司 2018-08-10 CN claimed
US-20250319056-A1 METHODS FOR TREATING CANCER UNIV INDIANA TRUSTEES (US) 2025-10-16 US disclosed
CN-105705489-B Compound as immunomodulator 百时美施贵宝公司 2019-04-26 CN disclosed
CN-108884093-A 6,7,8,9- tetrahydro -5H- pyrido [2,3-d] azepine * dopamine D 3 ligands 辉瑞公司 2018-11-23 CN disclosed
EP-3402796-A1 6,7,8,9-TETRAHYDRO-5H-PYRIDO[2,3-d]AZEPINE DOPAMINE D3 LIGANDS Pfizer Inc (US) 2018-11-21 EP disclosed
CN-108383828-A 1 new, 2- as chemokine receptor modulators is bis--sulfamide derivative 阿勒根公司 2018-08-10 CN disclosed
WO-2017122116-A1 6,7,8,9-TETRAHYDRO-5H-PYRIDO[2,3-d]AZEPINE DOPAMINE D3 LIGANDS PFIZER INC. (US) 2017-07-20 WO disclosed
WO-2007014273-A2 SULFONAMIDES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2007-02-01 WO disclosed
US-20070021495-A1 SULFONAMIDES AS SELECTIVE ESTROGEN RECEPTOR NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-01-25 US disclosed
EP-1345930-A2 PHARMACEUTICAL COMPOUNDS ELI LILLY AND COMPANY (US) 2003-09-24 EP disclosed
WO-2002050067-A2 PHARMACEUTICAL HETEROCYCLIC COMPOUNDS ELI LILLY AND COMPANY (US) 2002-06-27 WO disclosed
CN-1077888-C Benzopyrans and pharmaceutical compositions containing them NOVARTIS AG (CH) 2002-01-16 CN disclosed
EP-0828733-B1 BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM NOVARTIS AG (CH) 2001-09-05 EP disclosed
US-5905156-A POTASSIUM CHANNEL ACTIVATORS AND BRONCHODILATORS NOVARTIS AG (CH) 1999-05-18 US disclosed
US-5869478-A ADMINISTERING AS ANTIISCHEMIC AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-02-09 US disclosed
CN-1185153-A Benzopyrans and pharmaceutical composition contg. same CIBA GEIGY AG (CH) 1998-06-17 CN disclosed
EP-0828733-A1 BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Novartis AG (CH) 1998-03-18 EP disclosed
WO-1996037490-A1 BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM NOVARTIS AG (CH) 1996-11-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021495-A1 SULFONAMIDES AS SELECTIVE ESTROGEN RECEPTOR ESR1, ESR2, GPER1 STS 25/4885CA2 952/4885CA9 2114/4885
US-20250319056-A1 METHODS FOR TREATING CANCER HSP90AB1, HSP90B1, HSP90AB2P STS 4333/4885CA2 2002/4885CA9 2635/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.