Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 19/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4129123 | 0.93 | P2RX7 (0.86) | P2RX7 | |
| SCHEMBL4129972 | 0.89 | P2RX7 (0.74) | P2RX7 | |
| SCHEMBL4129949 | 0.88 | P2RX7 (0.69) | P2RX7 | |
| Azd9056 SCHEMBL29364060 | 0.88 | P2RX7 (1.00) | P2RX7 | |
| Azd9056 SCHEMBL4126642 | 0.88 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL4122056 | 0.88 | P2RX7 (0.92) | P2RX7 | |
| SCHEMBL4129931 | 0.87 | P2RX7 (0.71) | P2RX7 | |
| SCHEMBL4129203 | 0.87 | P2RX7 (0.71) | P2RX7 | |
| SCHEMBL4134555 | 0.87 | P2RX7 (0.74) | P2RX7 | |
| SCHEMBL4138789 | 0.87 | P2RX7 (0.94) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1862451-A1 | Adamantane derivatives for the treatment of inflammatory diseases | AstraZeneca AB (SE) | 2007-12-05 | — | — | EP | claimed |
| EP-1352896-A2 | Adamantane derivatives for the treatment of inflammatory, immune and cardiovascular diseases | AstraZeneca AB (SE) | 2003-10-15 | — | — | EP | claimed |
| US-6492355-B1 | Adamantane derivatives | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1171432-A1 | ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061569-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-10-19 | — | — | WO | disclosed |