Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | PRNP | P04156 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5336838 | 1.00 | HTT (0.50) | HTTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5477079 | 0.89 | HTT (0.61) | HTTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14467350 | 0.89 | HTT (0.61) | HTTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5444123 | 0.87 | HTT (0.48) | HTTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5444128 | 0.87 | HTT (0.48) | HTTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14466939 | 0.84 | HTT (0.46) | HTTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5335075 | 0.81 | HTT (0.59) | HTTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5335069 | 0.81 | HTT (0.59) | HTTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14466994 | 0.80 | HTT (0.56) | HTTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5337333 | 0.79 | HTT (0.71) | HTTALDH1A1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084868-A2 | TREATMENT OF DISORDERS BY ACTIVATION OF THE UNFOLDED PROTEIN RESPONSE | KALYPSYS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |