Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5335069 | 1.00 | HTT (0.59) | HTTSMN1; SMN2NPSR1CYP1A2CYP2C9 | |
| SCHEMBL14467350 | 0.81 | HTT (0.61) | HTTSMN1; SMN2NPSR1CYP1A2CYP2C9 | |
| SCHEMBL5477079 | 0.81 | HTT (0.61) | HTTSMN1; SMN2NPSR1CYP1A2CYP2C9 | |
| SCHEMBL9673208 | 0.81 | HTT (0.50) | HTTSMN1; SMN2NPSR1CYP1A2CYP2C9 | |
| SCHEMBL9673204 | 0.81 | HTT (0.50) | HTTSMN1; SMN2NPSR1CYP1A2CYP2C9 | |
| SCHEMBL5336833 | 0.81 | HTT (0.50) | HTTSMN1; SMN2NPSR1CYP1A2CYP2C9 | |
| SCHEMBL5336838 | 0.81 | HTT (0.50) | HTTSMN1; SMN2NPSR1CYP1A2CYP2C9 | |
| SCHEMBL14466823 | 0.80 | SMN1; SMN2 (0.57) | HTTSMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL14466994 | 0.76 | HTT (0.56) | HTTSMN1; SMN2NPSR1CYP1A2CYP2C9 | |
| SCHEMBL5337333 | 0.76 | HTT (0.71) | HTTSMN1; SMN2NPSR1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084868-A2 | TREATMENT OF DISORDERS BY ACTIVATION OF THE UNFOLDED PROTEIN RESPONSE | KALYPSYS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |