Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316994 | 0.93 | KDR (0.46) | ROCK2ROCK1GSK3AGSK3BPRKG1 | |
| SCHEMBL14466940 | 0.89 | KDR (0.49) | ROCK2ROCK1GSK3AGSK3BPRKG1 | |
| SCHEMBL5344443 | 0.87 | KDR (0.59) | TNIKIMPDH2KDRFLT1FLT4 | |
| SCHEMBL5334189 | 0.86 | FLT1 (0.52) | ROCK2ROCK1GSK3AGSK3BPRKG1 | |
| SCHEMBL5340799 | 0.85 | FLT1 (0.48) | ROCK2ROCK1GSK3AGSK3BPRKG1 | |
| SCHEMBL5318416 | 0.85 | TNIK (0.60) | ROCK2ROCK1GSK3AGSK3BPRKG1 | |
| SCHEMBL5341184 | 0.84 | FLT1 (0.50) | ROCK2ROCK1GSK3AGSK3BPRKG1 | |
| SCHEMBL5318108 | 0.84 | FLT1 (0.50) | ROCK2ROCK1GSK3AGSK3BPRKG1 | |
| SCHEMBL5334570 | 0.84 | KDR (0.44) | ROCK2ROCK1GSK3AGSK3BPRKG1 | |
| SCHEMBL5339024 | 0.84 | MAOB (0.47) | ROCK2ROCK1GSK3AGSK3BPRKG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |