Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.68 |
| ▸ | GAA | P10253 | 8/20 | 0.68 |
| ▸ | CASP1 | P29466 | 7/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | CASP7 | P55210 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.62 |
| ▸ | USP2 | O75604 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5335176 | 0.94 | ALDH1A1 (0.65) | ALDH1A1KDM4EGAACASP1MAPT | |
| SCHEMBL5334657 | 0.94 | GAA (0.63) | ALDH1A1KDM4EGAACASP1MAPT | |
| SCHEMBL5332917 | 0.92 | ALDH1A1 (0.61) | ALDH1A1KDM4EGAACASP1MAPT | |
| SCHEMBL5335812 | 0.92 | ALDH1A1 (0.71) | ALDH1A1KDM4EGAACASP1MAPT | |
| SCHEMBL5339867 | 0.90 | ALDH1A1 (0.68) | ALDH1A1KDM4EGAACASP1MAPT | |
| SCHEMBL5331105 | 0.88 | ALDH1A1 (0.64) | ALDH1A1KDM4EGAACASP1MAPT | |
| SCHEMBL5334382 | 0.86 | ALDH1A1 (0.81) | ALDH1A1KDM4EGAACASP1MAPT | |
| SCHEMBL5479853 | 0.86 | GAA (0.64) | ALDH1A1KDM4EGAACASP1MAPT | |
| SCHEMBL5332577 | 0.85 | ALDH1A1 (0.68) | ALDH1A1KDM4EGAACASP1MAPT | |
| SCHEMBL5478793 | 0.85 | GAA (0.66) | ALDH1A1KDM4EGAACASP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| WO-2007051062-A2 | SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | C3AR1, C5AR1, C5AR2 | ALDH1A1 1488/4885KDM4E 4033/4885GAA 3421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.