Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28988471 | 0.79 | ATM (0.61) | ATMNPSR1KDM4EPOLBALDH1A1 | |
| SCHEMBL2230907 | 0.79 | ATM (0.61) | ATMNPSR1KDM4EPOLBALDH1A1 | |
| SCHEMBL7892211 | 0.79 | NPSR1 (0.61) | ATMNPSR1KDM4EPOLBALDH1A1 | |
| SCHEMBL29710440 | 0.77 | ATM (0.73) | ATMNPSR1KDM4EPOLBALDH1A1 | |
| SCHEMBL29870198 | 0.76 | NPSR1 (1.00) | ATMNPSR1KDM4EPOLBALDH1A1 | |
| SCHEMBL581143 | 0.76 | NPSR1 (1.00) | ATMNPSR1KDM4EPOLBALDH1A1 | |
| SCHEMBL30989583 | 0.76 | ATM (0.56) | ATMNPSR1KDM4EPOLBALDH1A1 | |
| SCHEMBL10091947 | 0.76 | ATM (0.60) | ATMNPSR1KDM4EPOLBALDH1A1 | |
| SCHEMBL23496942 | 0.75 | ATM (0.59) | ATMNPSR1KDM4EPOLBALDH1A1 | |
| SCHEMBL30719641 | 0.75 | ATM (0.59) | ATMNPSR1KDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794148-A1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006032518-A1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-30 | — | — | WO | disclosed |