Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | CCR3 | P51677 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.44 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.42 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14466898 | 0.92 | GRIN2D (0.53) | HRH1CCR3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL14466897 | 0.92 | EPHX2 (0.45) | HRH1CCR3KMT2AGRIN2DGRIN3B | |
| SCHEMBL14467021 | 0.91 | EPHX2 (0.46) | HRH1CCR3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL14466893 | 0.90 | HRH1 (0.52) | HRH1CCR3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL14467000 | 0.88 | KMT2A (0.44) | KMT2AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL14467002 | 0.86 | EPHX2 (0.43) | HRH1CCR3KMT2AEPHX2NAMPT | |
| SCHEMBL14466997 | 0.84 | KMT2A (0.39) | HRH1CCR3KMT2AGRIN2DGRIN3B | |
| SCHEMBL14467006 | 0.84 | KMT2A (0.39) | HRH1CCR3KMT2AGRIN2DGRIN3B | |
| SCHEMBL14467008 | 0.83 | GRIN2D (0.52) | HRH1CCR3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL14466907 | 0.83 | MMP1 (0.43) | KMT2AGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007082079-A2 | PIPERIDINE AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-19 | — | — | WO | disclosed |
| WO-2007082079-A2 | PIPERIDINE AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-19 | — | — | WO | disclosed |