Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 3/20 | 0.41 |
| ▸ | HMGCR | P04035 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 3/20 | 0.36 |
| ▸ | CES1 | P23141 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 4/20 | 0.34 |
| ▸ | PPARD | Q03181 | 4/20 | 0.34 |
| ▸ | PPARA | Q07869 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6257072 | 1.00 | PTPN7 (0.41) | PTPN7HMGCRMAPTKMT2ATDP1 | |
| SCHEMBL8045294 | 1.00 | PTPN7 (0.41) | PTPN7HMGCRMAPTKMT2ATDP1 | |
| SCHEMBL974861 | 0.91 | — | — | |
| SCHEMBL27371777 | 0.84 | KMT2A (0.59) | PTPN7HMGCRMAPTKMT2ATDP1 | |
| SCHEMBL8060807 | 0.84 | KMT2A (0.48) | PTPN7HMGCRMAPTKMT2ATDP1 | |
| SCHEMBL1019921 | 0.84 | KMT2A (0.59) | PTPN7HMGCRMAPTKMT2ATDP1 | |
| SCHEMBL10607844 | 0.84 | KMT2A (0.54) | PTPN7HMGCRMAPTKMT2ATDP1 | |
| SCHEMBL2452930 | 0.84 | KMT2A (0.59) | PTPN7HMGCRMAPTKMT2ATDP1 | |
| SCHEMBL9421864 | 0.84 | KMT2A (0.59) | PTPN7HMGCRMAPTKMT2ATDP1 | |
| SCHEMBL17776278 | 0.83 | TDP1 (0.56) | MAPTKMT2ATDP1HAO1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247629-B2 | Antitumoral analogs of et-743 | PHARMA MAR, S.A. | 2007-07-24 | — | — | US | disclosed |
| US-20040019056-A1 | Anititumoral analogs of et-743 | PHARMA MAR, S.A. (ES) | 2004-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019056-A1 | Anititumoral analogs of et-743 | ETV1, ETV6, MATR3 | PTPN7 2254/4885HMGCR 4281/4885MAPT 3798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.