Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534009 | 0.89 | PTGDR2 (0.32) | PTGDR2EPHX2HTR2AKCNH2CRHR1 | |
| SCHEMBL534858 | 0.88 | PTGDR2 (0.39) | PTGDR2CYP19A1 | |
| SCHEMBL533922 | 0.85 | PTGDR2 (0.49) | PTGDR2EPHX2TSHR | |
| SCHEMBL533980 | 0.84 | PTGDR2 (0.41) | PTGDR2EPHX2LMNAMAPT | |
| SCHEMBL534921 | 0.77 | PTGDR2 (0.49) | PTGDR2CYP19A1 | |
| SCHEMBL534857 | 0.77 | PTGDR2 (0.39) | PTGDR2SMN1; SMN2 | |
| SCHEMBL534813 | 0.73 | PTGDR2 (0.58) | PTGDR2MAPTTSHR | |
| SCHEMBL534580 | 0.72 | MRGPRX4 (0.35) | PTGDR2EPHX2HTR2AKCNH2LMNA | |
| SCHEMBL534686 | 0.72 | PTGDR2 (0.49) | PTGDR2LMNAMAPTTSHRSMN1; SMN2 | |
| SCHEMBL533987 | 0.69 | AR (0.36) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129661-B1 | QUINOLINE DERIVATIVES AS CRTH2 RECEPTOR LIGANDS | PULMAGEN THERAPEUTICS ASTHMA LTD (GB) | 2012-02-08 | — | — | EP | claimed |