Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5340651 | 1.00 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1POLBKDM4ETSHR | |
| SCHEMBL5339956 | 0.89 | PTK2 (0.67) | SMN1; SMN2ALDH1A1POLBKDM4ETSHR | |
| SCHEMBL5339948 | 0.89 | PTK2 (0.67) | SMN1; SMN2ALDH1A1POLBKDM4ETSHR | |
| SCHEMBL14542391 | 0.87 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1POLBKDM4ETSHR | |
| SCHEMBL5339915 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1POLBKDM4ETSHR | |
| SCHEMBL14542416 | 0.86 | TP53 (0.69) | SMN1; SMN2ALDH1A1POLBKDM4ETSHR | |
| SCHEMBL14542108 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1POLBKDM4ETSHR | |
| SCHEMBL5339920 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1POLBKDM4ETSHR | |
| SCHEMBL14542418 | 0.86 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1POLBKDM4ETSHR | |
| SCHEMBL14542393 | 0.86 | MEN1 (0.54) | SMN1; SMN2ALDH1A1KDM4ETSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007047394-A2 | THIOTRIAZOLYL DERIVATIVES | EPIX DELAWARE, INC. (US) | 2007-04-26 | — | — | WO | claimed |
| WO-2007047394-A2 | THIOTRIAZOLYL DERIVATIVES | EPIX DELAWARE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |