Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 5/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 3/20 | 0.40 |
| ▸ | CCND1 | P24385 | 3/20 | 0.40 |
| ▸ | NOS1 | P29475 | 4/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 5/20 | 0.38 |
| ▸ | PPARA | Q07869 | 5/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | JUN | P05412 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341690 | 0.88 | USP30 (0.48) | MAPK14USP30 | |
| SCHEMBL5914261 | 0.77 | USP30 (0.33) | MAPK14CDK2MAPK8JUNMAPK9 | |
| SCHEMBL5914262 | 0.74 | MAPK14 (0.37) | MAPK14 | |
| SCHEMBL5914088 | 0.73 | USP30 (0.46) | MAPK14USP30 | |
| SCHEMBL5914172 | 0.72 | MAPK14 (0.35) | MAPK14USP30 | |
| SCHEMBL5267139 | 0.71 | ACACB (0.41) | USP30 | |
| SCHEMBL5914255 | 0.71 | SCD (0.36) | MAPK14 | |
| SCHEMBL5317262 | 0.70 | MAPK8 (0.39) | MAPK14NOS2CDK2CDK1NOS1 | |
| SCHEMBL5264929 | 0.70 | IRAK1 (0.41) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL5913964 | 0.70 | MAPK8 (0.44) | MAPK14CDK2CDK1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | claimed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | claimed |