Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.44 |
| ▸ | JUN | P05412 | 3/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 5/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914134 | 0.89 | MAPK8 (0.44) | MAPK8MAPK9JUNMAPK10CDK2 | |
| SCHEMBL5914219 | 0.86 | VCP (0.48) | MAPK1TP53ALOX15CASP1CASP7 | |
| SCHEMBL5266019 | 0.86 | MAPK8 (0.54) | MAPK8MAPK9MAPK10CDK2MAPK14 | |
| SCHEMBL5914214 | 0.85 | MAPK8 (0.41) | MAPK8MAPK9JUNMAPK10CDK2 | |
| SCHEMBL5914206 | 0.85 | MAPK8 (0.41) | MAPK8MAPK9JUNMAPK10CDK2 | |
| SCHEMBL5913810 | 0.82 | MAPK8 (0.48) | MAPK8MAPK9JUNMAPK10CDK2 | |
| SCHEMBL5913811 | 0.82 | MAPK8 (0.42) | MAPK8MAPK9MAPK10CDK2MAPK14 | |
| SCHEMBL5913834 | 0.82 | MAPK8 (0.42) | MAPK8MAPK9MAPK10CDK2MAPK14 | |
| SCHEMBL5914425 | 0.81 | IKBKB (0.47) | MAPK8TP53HSD17B10CDK2CDK1 | |
| SCHEMBL5264825 | 0.81 | MAPK14 (0.43) | MAPK8MAPK9JUNMAPK10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069110-A1 | Substituted heterocyclic compounds and methods of use | MAPT, MYLK2, IAPP | MAPK8 1760/4885MAPK9 2753/4885JUN 1058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.