Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | TYMP | P19971 | 1/20 | 0.52 |
| ▸ | ATG7 | O95352 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.49 |
| ▸ | UBA7 | P41226 | 1/20 | 0.49 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.49 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | TARS1 | P26639 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800307 | 1.00 | CA1 (0.55) | CA1CA2CA4CA9TYMP | |
| SCHEMBL12617951 | 1.00 | CA1 (0.55) | CA1CA2CA4CA9TYMP | |
| SCHEMBL1797504 | 0.85 | LARS1 (0.49) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL18630612 | 0.85 | LARS1 (0.49) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL1796936 | 0.85 | MEN1 (0.65) | TYMPMEN1KMT2AADORA3 | |
| SCHEMBL6635214 | 0.85 | MEN1 (0.65) | TYMPMEN1KMT2AADORA3 | |
| SCHEMBL21480367 | 0.80 | TYMP (0.56) | TYMPMEN1KMT2AADORA3 | |
| SCHEMBL5321913 | 0.79 | ATG7 (0.63) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL1796966 | 0.79 | ATG7 (0.63) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL1796531 | 0.79 | RXFP1 (0.69) | CA1CA2CA4CA9TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848718-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006084281-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | disclosed |