Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 7/20 | 0.61 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5349262 | 0.86 | CDK5 (0.58) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5341973 | 0.85 | CDK5 (0.58) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5345069 | 0.82 | RAB9A (0.39) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5342480 | 0.82 | CDK5 (0.56) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5343136 | 0.81 | CDK5 (0.66) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5341105 | 0.80 | CDK5 (0.81) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL14569530 | 0.80 | CDK5 (0.70) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5337543 | 0.79 | CDK5 (0.47) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5345140 | 0.79 | CDK5 (0.69) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5342009 | 0.79 | CDK5 (0.69) | CDK5CDK5R1ROCK1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |