Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 14/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5340681 | 0.91 | HRH2 (0.48) | HRH2CYP1A2CYP2C9CYP2C19DRD2 | |
| SCHEMBL5345523 | 0.87 | CNR1 (0.53) | HRH2CYP1A2CYP2C9CYP2C19CNR1 | |
| SCHEMBL5346296 | 0.83 | HRH2 (0.48) | HRH2CYP1A2CYP2C9CYP2C19CNR1 | |
| SCHEMBL5342134 | 0.82 | HRH2 (0.50) | HRH2DRD2SLC6A4 | |
| SCHEMBL5341750 | 0.80 | HRH2 (0.63) | HRH2DRD2SLC6A4BRD4 | |
| SCHEMBL5344741 | 0.79 | SLC6A4 (0.42) | HRH2DRD2SLC6A4CNR1CNR2 | |
| SCHEMBL5347587 | 0.78 | CYP1A2 (0.50) | HRH2CYP1A2CYP2C9CYP2C19DRD2 | |
| SCHEMBL5354709 | 0.78 | HRH2 (0.64) | HRH2DRD2SLC6A4 | |
| SCHEMBL5343718 | 0.78 | HRH2 (0.73) | HRH2 | |
| SCHEMBL5345690 | 0.77 | HRH2 (0.73) | HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189741-B2 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents | ALMIRALL PRODESFARMA S.A. (ES) | 2007-03-13 | — | — | US | disclosed |
| EP-1330453-B1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA SA (ES) | 2006-03-29 | — | — | EP | disclosed |
| US-20040116471-A1 | Indolylpiperidine derivatives as antihistaminic aand antiallergic agents | ALMIRALL PRODESFARMA S.A. (ES) | 2004-06-17 | — | — | US | disclosed |
| EP-1330453-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002036589-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA S.A. (ES) | 2002-05-10 | — | — | WO | disclosed |