Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 13/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5347587 | 0.90 | CYP1A2 (0.50) | CYP1A2CYP2C9CYP2C19HRH2HTR2A | |
| SCHEMBL5344576 | 0.87 | HRH2 (0.47) | CNR1CNR2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5346296 | 0.87 | HRH2 (0.48) | CNR1CNR2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14559252 | 0.83 | KDM4E (0.51) | HRH2HTR2AHTR2CHTR2BUSP2 | |
| SCHEMBL4055298 | 0.82 | HRH2 (0.66) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL4063089 | 0.82 | HRH2 (0.55) | HRH2HTR2AHTR2CHTR2BHSD17B10 | |
| SCHEMBL5356085 | 0.81 | HRH2 (0.62) | CNR1CNR2HRH2HTR2AHTR2C | |
| SCHEMBL5346890 | 0.81 | HRH2 (0.59) | HRH2HTR2AHTR2CHTR2BUSP2 | |
| SCHEMBL6784820 | 0.80 | KDM4E (0.48) | CNR1HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL5347830 | 0.80 | CNR2 (0.53) | CNR1CNR2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189741-B2 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents | ALMIRALL PRODESFARMA S.A. (ES) | 2007-03-13 | — | — | US | disclosed |
| EP-1330453-B1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA SA (ES) | 2006-03-29 | — | — | EP | disclosed |
| US-20040116471-A1 | Indolylpiperidine derivatives as antihistaminic aand antiallergic agents | ALMIRALL PRODESFARMA S.A. (ES) | 2004-06-17 | — | — | US | disclosed |
| EP-1330453-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002036589-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA S.A. (ES) | 2002-05-10 | — | — | WO | disclosed |