Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29499693 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRGRIN2DGRIN3B | |
| SCHEMBL2818765 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRGRIN2DGRIN3B | |
| SCHEMBL11314500 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRGRIN2DGRIN3B | |
| SCHEMBL4079663 | 0.78 | POLB (0.50) | ALDH1A1TDP1TSHRGRIN2DGRIN3B | |
| SCHEMBL27962640 | 0.76 | POLB (0.59) | ALDH1A1TDP1TSHRGRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL2861569 | 0.76 | POLB (0.49) | ALDH1A1TDP1TSHRGRIN2DGRIN3B | |
| SCHEMBL10408239 | 0.76 | ALDH1A1 (0.44) | ALDH1A1TDP1TSHRGRIN2DGRIN3B | |
| SCHEMBL19718451 | 0.76 | ALDH1A1 (0.44) | ALDH1A1TDP1TSHRGRIN2DGRIN3B | |
| SCHEMBL3191024 | 0.76 | ALDH1A1 (0.59) | ALDH1A1TDP1TSHRGRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL28777084 | 0.74 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312334-B2 | Method of preparing inhibitors phosphodiesterase-4 | MERCK & CO. INC. (US) | 2007-12-25 | — | — | US | disclosed |
| US-20060019981-A1 | Method of preparing inhibitors phosphodiesterase-4 | MERCK & CO., INC. | 2006-01-26 | — | — | US | disclosed |
| EP-1565466-A2 | METHOD OF PREPARING INHIBITORS OF PHOSPHODIESTERASE-4 | Merck & Co., Inc. (US) | 2005-08-24 | — | — | EP | disclosed |
| US-6909002-B2 | Method of preparing inhibitors of phosphodiesterase-4 | MERCK & CO., INC. (US) | 2005-06-21 | — | — | US | disclosed |
| WO-2004048377-A2 | METHOD OF PREPARING INHIBITORS OF PHOSPHODIESTERASE-4 | MERCK & CO., INC. (US) | 2004-06-10 | — | — | WO | disclosed |
| US-20040102472-A1 | Method of preparing inhibitors of phosphodiesterase-4 | MERCK & CO., INC. | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102472-A1 | Method of preparing inhibitors of phosphodiesterase-4 | PDE4B, PDE4A, PDE5A | ALDH1A1 558/4885TDP1 103/4885TSHR 2757/4885 |
| US-20060019981-A1 | Method of preparing inhibitors phosphodiesterase-4 | PDE4A, PDE5A, PDE3A | ALDH1A1 572/4885TDP1 205/4885TSHR 2569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.