Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023157 | 0.86 | ALDH1A1 (0.40) | ALDH1A1TP53MEN1TSHRKMT2A | |
| SCHEMBL4023946 | 0.81 | ALDH1A1 (0.41) | ALDH1A1HPGDHSD17B10MEN1TSHR | |
| SCHEMBL4953627 | 0.81 | PTPN1 (0.46) | ALDH1A1HPGDHSD17B10MEN1TSHR | |
| SCHEMBL4024325 | 0.75 | PSEN1 (0.42) | ALDH1A1HPGDHSD17B10TP53RAB9A | |
| SCHEMBL4192744 | 0.75 | ALDH1A1 (0.34) | ALDH1A1HPGDHSD17B10MEN1TSHR | |
| SCHEMBL4022869 | 0.75 | PTPN1 (0.52) | ALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL4192748 | 0.72 | ALDH1A1 (0.35) | ALDH1A1HPGDHSD17B10TP53MEN1 | |
| SCHEMBL4024279 | 0.71 | PSEN1 (0.53) | ALDH1A1HPGDHSD17B10MEN1TSHR | |
| SCHEMBL4021086 | 0.71 | PTPN1 (0.37) | ALDH1A1HPGDHSD17B10TP53MEN1 | |
| SCHEMBL4023360 | 0.71 | ALDH1A1 (0.32) | ALDH1A1HPGDHSD17B10MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397356-A1 | SUBSTITUTED NAPHTHYL INDOLE DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | Wyeth (US) | 2004-03-17 | — | — | EP | claimed |
| WO-2003000684-A1 | SUBSTITUTED NAPHTHYL INDOLE DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH (US) | 2003-01-03 | — | — | WO | claimed |
| WO-2007092207-A1 | COMPOSITIONS FOR THE DELIVERY OF SUBSTITUTED NAPHTHYL INDOLE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |
| EP-1397356-A1 | SUBSTITUTED NAPHTHYL INDOLE DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | Wyeth (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2003000684-A1 | SUBSTITUTED NAPHTHYL INDOLE DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH (US) | 2003-01-03 | — | — | WO | disclosed |