SCHEMBL5345778

SCHEMBL5345778

CCOc1ccc(CC(CC)C(=O)O)cc1CNC(=O)c1ccc(Oc2ccccn2)cc1

nearest known ligand 0.69

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARG P37231 19/20 0.69
PPARD Q03181 14/20 0.69
PPARA Q07869 14/20 0.69
EPHX2 P34913 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5350836 0.87 PPARA (0.67) PPARGPPARDPPARAEPHX2
SCHEMBL3945192 0.82 PPARA (1.00) PPARGPPARDPPARAEPHX2
SCHEMBL5350230 0.81 PPARA (0.80) PPARGPPARDPPARA
SCHEMBL5362876 0.78 PPARA (0.83) PPARGPPARDPPARAEPHX2
SCHEMBL3945781 0.77 PPARA (1.00) PPARGPPARDPPARA
SCHEMBL30938048 0.77 PPARG (1.00) PPARG
SCHEMBL6505382 0.75 PPARA (0.81) PPARGPPARDPPARA
SCHEMBL28658560 0.74 PPARG (1.00) PPARGPPARDPPARAEPHX2
SCHEMBL6496409 0.74 PPARA (0.70) PPARGPPARDPPARA
SCHEMBL3943372 0.72 PPARD (1.00) PPARGPPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7176204-B2 Substituted carboxylic acid derivatives KYORIN PAHRMACEUTICAL CO., LTD. (JP) 2007-02-13 US claimed
US-20050101521-A1 Substituted carboxylic acid derivatives KYORIN PHARMACEUTICAL CO., LTD. (JP) 2005-05-12 US claimed
EP-1348698-A1 SUBSTITUTED CARBOXYLIC ACID DERIVATIVES Kyorin Pharmaceutical Co., Ltd. (JP) 2003-10-01 EP claimed
US-7176204-B2 Substituted carboxylic acid derivatives KYORIN PAHRMACEUTICAL CO., LTD. (JP) 2007-02-13 US disclosed
US-7176204-B2 Substituted carboxylic acid derivatives KYORIN PAHRMACEUTICAL CO., LTD. (JP) 2007-02-13 US disclosed
US-7176204-B2 Substituted carboxylic acid derivatives KYORIN PAHRMACEUTICAL CO., LTD. (JP) 2007-02-13 US disclosed
US-20050101521-A1 Substituted carboxylic acid derivatives KYORIN PHARMACEUTICAL CO., LTD. (JP) 2005-05-12 US disclosed
EP-1348698-A1 SUBSTITUTED CARBOXYLIC ACID DERIVATIVES Kyorin Pharmaceutical Co., Ltd. (JP) 2003-10-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050101521-A1 Substituted carboxylic acid derivatives PPARG, PPARA, PPARD PPARG 1/4885PPARD 3/4885PPARA 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.