Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PRNP | P04156 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5345792 | 1.00 | HTT (0.52) | HTTLMNAPRNPRECQLALDH1A1 | |
| SCHEMBL5347120 | 0.85 | HTT (0.50) | HTTLMNAPRNPRECQLALDH1A1 | |
| SCHEMBL5337333 | 0.84 | HTT (0.71) | HTTLMNAPRNPRECQLALDH1A1 | |
| SCHEMBL5337340 | 0.84 | HTT (0.71) | HTTLMNAPRNPRECQLALDH1A1 | |
| SCHEMBL14466996 | 0.83 | HTT (0.48) | HTTLMNAPRNPRECQLALDH1A1 | |
| SCHEMBL14466994 | 0.74 | HTT (0.56) | HTTLMNAPRNPRECQLALDH1A1 | |
| SCHEMBL5342520 | 0.74 | HTT (0.69) | HTTLMNAPRNPRECQLALDH1A1 | |
| SCHEMBL5342525 | 0.74 | HTT (0.69) | HTTLMNAPRNPRECQLALDH1A1 | |
| SCHEMBL9673208 | 0.73 | HTT (0.50) | HTTLMNARECQLALDH1A1KMT2A | |
| SCHEMBL9673204 | 0.73 | HTT (0.50) | HTTLMNARECQLALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084868-A2 | TREATMENT OF DISORDERS BY ACTIVATION OF THE UNFOLDED PROTEIN RESPONSE | KALYPSYS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |