Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 3/20 | 0.63 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.63 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.60 |
| ▸ | AXL | P30530 | 1/20 | 0.60 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.60 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5788420 | 0.96 | CDK5 (0.70) | CDK5CDK5R1CYP19A1AXLPBRM1 | |
| SCHEMBL5345119 | 0.93 | CDK5 (0.67) | CDK5CDK5R1CYP19A1AXLPBRM1 | |
| SCHEMBL5342305 | 0.91 | CDK5 (0.77) | CDK5CDK5R1CYP19A1AXLPBRM1 | |
| SCHEMBL5337575 | 0.90 | CYP19A1 (0.60) | CDK5CDK5R1CYP19A1AXLPBRM1 | |
| SCHEMBL14558736 | 0.89 | CDK5 (0.54) | CDK5CDK5R1CYP19A1AXLPBRM1 | |
| SCHEMBL5346853 | 0.89 | EGFR (0.54) | CDK5CDK5R1CYP19A1AXLPBRM1 | |
| SCHEMBL6758522 | 0.89 | HDAC6 (0.58) | CDK5CDK5R1CYP19A1AXLPBRM1 | |
| SCHEMBL5347542 | 0.88 | CDK5 (0.56) | CDK5CDK5R1CYP19A1AXLPBRM1 | |
| SCHEMBL5338292 | 0.87 | CDK5 (0.55) | CDK5CDK5R1CYP19A1AXLPBRM1 | |
| SCHEMBL5339323 | 0.87 | LMNA (0.61) | CDK5CDK5R1CYP19A1AXLPBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| EP-1619184-A2 | Urea compounds as kinase inhibitors | Amgen, Inc. (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1483263-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003070727-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-08-28 | — | — | WO | disclosed |
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |