⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21198402 | 0.97 | — | — | |
| SCHEMBL1880617 | 0.73 | — | — | |
| SCHEMBL20886569 | 0.71 | CYP4F2 (0.36) | — | |
| SCHEMBL15776833 | 0.71 | — | — | |
| SCHEMBL19629045 | 0.71 | — | — | |
| SCHEMBL9058110 | 0.71 | — | — | |
| SCHEMBL31423335 | 0.71 | — | — | |
| SCHEMBL2284348 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL11251317 | 0.71 | — | — | |
| SCHEMBL27393706 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144743-A1 | COMPOUNDS | TMEM16A LIMITED (GB) | 2026-05-28 | — | — | US | disclosed |
| EP-4699655-A2 | COMPOUNDS | TMEM16A LIMITED (GB) | 2026-02-25 | — | — | EP | disclosed |
| US-20250376468-A1 | PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS | UNIV LEUVEN KATH (BE) | 2025-12-11 | — | — | US | disclosed |
| US-12377105-B2 | Compounds | TMEM16A LIMITED (GB) | 2025-08-05 | — | — | US | disclosed |
| CN-119998280-A | Pyrazolo [1,5-a ] pyridine derivatives for the treatment of TRPM3 mediated disorders | 勒芬天主教大学 | 2025-05-13 | — | — | CN | disclosed |
| CN-119490451-A | Compounds as positive modulators of calcium activated chloride channels | TMEM16A有限公司 | 2025-02-21 | — | — | CN | disclosed |
| EP-4499636-A2 | PYRAZOLO[1,5-A]PYRIDINE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS | Katholieke Universiteit Leuven KU Leuven Research & Development (BE) | 2025-02-05 | — | — | EP | disclosed |
| CN-111683926-B | Compounds of formula (I) | 企业治疗学有限公司 | 2024-11-08 | — | — | CN | disclosed |
| US-12116343-B2 | Inhibitors of APOL1 and methods of using same | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2024-10-15 | — | — | US | disclosed |
| WO-2023230542-A2 | PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-11-30 | — | — | WO | disclosed |
| US-20080194694-A1 | nematocides such as N-{1-cyano-2-[5-cyano-2-(trifluoromethyl)phenoxy]-1-methylethyl}-4-pentafluorothiobenzamide, tautomers or prodrugs, carriers and optionally a second therapeutic agent, used for treating parasitic infestations | PFIZER LIMITED (UK) | 2008-08-14 | — | — | US | disclosed |
| US-20080194694-A1 | nematocides such as N-{1-cyano-2-[5-cyano-2-(trifluoromethyl)phenoxy]-1-methylethyl}-4-pentafluorothiobenzamide, tautomers or prodrugs, carriers and optionally a second therapeutic agent, used for treating parasitic infestations | PFIZER LIMITED (UK) | 2008-08-14 | — | — | US | disclosed |
| US-20080194694-A1 | nematocides such as N-{1-cyano-2-[5-cyano-2-(trifluoromethyl)phenoxy]-1-methylethyl}-4-pentafluorothiobenzamide, tautomers or prodrugs, carriers and optionally a second therapeutic agent, used for treating parasitic infestations | PFIZER LIMITED (UK) | 2008-08-14 | — | — | US | disclosed |
| US-20070072944-A1 | Amidoacetonitrile derivatives | ELANCO TIERGESUNDHEIT AG (CH) | 2007-03-29 | — | — | US | disclosed |
| CN-1902162-A | Acylaminoacetonitrile derivatives | NOVARTIS AG (CH) | 2007-01-24 | — | — | CN | disclosed |
| EP-1682493-A1 | AMIDOACETONITRILE DERIVATIVES | Novartis AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005044784-A1 | AMIDOACETONITRILE DERIVATIVES | NOVARTIS AG (CH) | 2005-05-19 | — | — | WO | disclosed |
| WO-2003004474-A1 | PESTICIDALLY ACTIVE AMINOACETONITRILES | SYNGENTA PARTICIPATIONS AG (CH) | 2003-01-16 | — | — | WO | disclosed |
| US-4873256-A | Antiandrogenic 4-hydroxymethyl-2-imidazolidine-diones | Uclaf, Roussel (FR) | 1989-10-10 | — | — | US | disclosed |
| EP-0305270-A1 | Imidazolidines substituted by a hydroxymethyl and a substituted phenyl radical, process for their preparation, their use as medicines, pharmaceutical compositions containing them and an intermediate for their preparation | ROUSSEL-UCLAF (FR) | 1989-03-01 | — | — | EP | disclosed |