SCHEMBL5347308

SCHEMBL5347308

O=c1[nH]c(=O)n(Cc2cc(F)cc(F)c2)cc1I

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.44
CYP1A2 P05177 1/20 0.44
GRIA1 P42261 1/20 0.44
GRIA2 P42262 1/20 0.44
GRIA4 P48058 1/20 0.44
BLM P54132 1/20 0.44
GRIK5 Q16478 1/20 0.44
HSD17B10 Q99714 1/20 0.44
DAO P14920 2/20 0.43
HPGD P15428 1/20 0.41
DBH P09172 1/20 0.40
TYMP P19971 1/20 0.39
MEN1 O00255 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4176930 0.84 TYMP (0.48) KMT2ACYP1A2GRIA1GRIA2GRIA4
SCHEMBL4172709 0.78 HPGD (0.67) KMT2ACYP1A2GRIA1GRIA2GRIA4
SCHEMBL12169429 0.75 HPGD (0.59) HPGD
SCHEMBL7839293 0.73 TYMP (0.52) KMT2ADAOHPGDTYMPMEN1
SCHEMBL4172004 0.72 HPGD (0.44) KMT2ACYP1A2GRIA1GRIA2GRIA4
SCHEMBL4163074 0.71 L3MBTL1 (0.50) DAOHPGD
SCHEMBL22085424 0.70 HPGD (0.49) KMT2ACYP1A2GRIA1GRIA2GRIA4
SCHEMBL30072144 0.70 DBH (0.41) DAODBH
SCHEMBL12501014 0.69 HPGD (0.48) KMT2ADAOHPGDMEN1
SCHEMBL24282370 0.67 DBH (0.33) DBH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007122634-A2 PYRIMIDINEDIONES AS TYROSINE KINASE INHIBITORS JUBILANT BIOSYS LIMITED (IN) 2007-11-01 WO disclosed