Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.53 |
| ▸ | HTR2A | P28223 | 4/20 | 0.53 |
| ▸ | HTR2B | P41595 | 4/20 | 0.53 |
| ▸ | HRH2 | P25021 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341180 | 0.82 | HTR6 (0.44) | HTR2CHTR2AHTR2BHRH2HTR6 | |
| SCHEMBL5350942 | 0.82 | HTR6 (0.46) | HTR2CHTR2AHTR2BHRH2HTR6 | |
| SCHEMBL5343906 | 0.82 | HTR2A (0.58) | HTR2CHTR2AHTR2BHRH2HTR6 | |
| SCHEMBL5350384 | 0.81 | HTR2A (0.57) | HTR2CHTR2AHTR2BHRH2LMNA | |
| SCHEMBL5358649 | 0.80 | HRH2 (0.48) | HTR2CHTR2AHTR2BHRH2HTR6 | |
| SCHEMBL5344681 | 0.79 | HTR2C (0.48) | HTR2CHTR2AHTR2BHRH2HTR6 | |
| SCHEMBL5347249 | 0.78 | HRH2 (0.56) | HTR2CHTR2AHTR2BHRH2HTR6 | |
| SCHEMBL5344282 | 0.77 | HTR2A (0.78) | HTR2CHTR2AHTR2BHRH2 | |
| SCHEMBL4052722 | 0.76 | HTR2A (0.44) | HTR2CHTR2AHTR2BHRH2HTR6 | |
| SCHEMBL4490329 | 0.75 | HTR6 (0.53) | HTR2CHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189741-B2 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents | ALMIRALL PRODESFARMA S.A. (ES) | 2007-03-13 | — | — | US | disclosed |
| EP-1330453-B1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA SA (ES) | 2006-03-29 | — | — | EP | disclosed |
| US-20040116471-A1 | Indolylpiperidine derivatives as antihistaminic aand antiallergic agents | ALMIRALL PRODESFARMA S.A. (ES) | 2004-06-17 | — | — | US | disclosed |
| EP-1330453-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002036589-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA S.A. (ES) | 2002-05-10 | — | — | WO | disclosed |