Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534799 | 1.00 | LMNA (0.41) | LMNAMEN1KMT2AS1PR1NPC1 | |
| SCHEMBL405072 | 0.92 | LMNA (0.39) | LMNAMEN1KMT2AS1PR1RAB9A | |
| SCHEMBL405071 | 0.92 | LMNA (0.39) | LMNAMEN1KMT2AS1PR1RAB9A | |
| SCHEMBL10170446 | 0.92 | LMNA (0.39) | LMNAMEN1KMT2AS1PR1RAB9A | |
| SCHEMBL10170373 | 0.86 | S1PR1 (0.38) | LMNAS1PR1NPC1RAB9ANR1D1 | |
| SCHEMBL409765 | 0.86 | S1PR1 (0.38) | LMNAS1PR1NPC1RAB9ANR1D1 | |
| SCHEMBL409764 | 0.86 | S1PR1 (0.38) | LMNAS1PR1NPC1RAB9ANR1D1 | |
| SCHEMBL408854 | 0.79 | SLC6A2 (0.37) | LMNAMEN1KMT2AS1PR1SMN1; SMN2 | |
| SCHEMBL10170444 | 0.79 | SLC6A2 (0.37) | LMNAMEN1KMT2AS1PR1SMN1; SMN2 | |
| SCHEMBL408853 | 0.79 | SLC6A2 (0.37) | LMNAMEN1KMT2AS1PR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414342-A1 | OXADIAZOLE DERIVATIVES | Merck Serono S.A. (CH) | 2012-02-08 | — | — | EP | disclosed |
| EP-2414341-A2 | OXADIAZOLE DERIVATIVES | Merck Serono SA (CH) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010115751-A2 | OXADIAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010112461-A1 | OXADIAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2010-10-07 | — | — | WO | disclosed |