Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL256679 | 0.87 | — | — | |
| Trifluoroacetic Acid SCHEMBL1998431 | 0.82 | TDP1 (0.47) | TDP1FAAHPOLBKDM4EMLYCD | |
| SCHEMBL8598528 | 0.81 | PLG (0.48) | TDP1FAAHPOLBCKS1BSKP1 | |
| SCHEMBL8598524 | 0.81 | PLG (0.48) | TDP1FAAHPOLBCKS1BSKP1 | |
| SCHEMBL4761356 | 0.81 | TDP1 (0.48) | TDP1FAAHPOLBCKS1BSKP1 | |
| Trifluoroacetic Acid SCHEMBL21813736 | 0.81 | CYP2D6 (0.52) | TDP1MLYCDHDAC6ALDH1A1CYP3A4 | |
| SCHEMBL13686045 | 0.79 | TDP1 (0.47) | TDP1FAAHPOLBCKS1BSKP1 | |
| SCHEMBL14094370 | 0.79 | TDP1 (0.47) | TDP1FAAHPOLBCKS1BSKP1 | |
| SCHEMBL19151014 | 0.79 | TDP1 (0.47) | TDP1FAAHPOLBCKS1BSKP1 | |
| SCHEMBL21941874 | 0.79 | EPHX1 (0.48) | TDP1FAAHPOLBCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7214699-B2 | Indazole derivatives as CRF antagonists | ROCHE PALO ALTO LLC (US) | 2007-05-08 | — | — | US | disclosed |