Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | IDH1 | O75874 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PPID | Q08752 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14625975 | 0.88 | POLB (0.55) | POLBIDH1NPSR1L3MBTL1MAPT | |
| SCHEMBL23310334 | 0.86 | POLB (0.62) | POLBIDH1L3MBTL1NPC1RAB9A | |
| SCHEMBL10704732 | 0.86 | POLB (0.62) | POLBIDH1NPSR1L3MBTL1NPC1 | |
| SCHEMBL5112169 | 0.85 | POLB (0.50) | POLBIDH1NPSR1L3MBTL1NPC1 | |
| SCHEMBL1441875 | 0.84 | POLB (0.57) | POLBIDH1NPSR1L3MBTL1NPC1 | |
| Hydrochloric Acid SCHEMBL5773679 | 0.84 | POLB (0.49) | POLBIDH1NPSR1L3MBTL1NPC1 | |
| SCHEMBL27350327 | 0.84 | MEN1 (0.65) | POLBIDH1NPSR1NPC1RAB9A | |
| SCHEMBL696485 | 0.82 | IDH1 (0.62) | POLBIDH1NPSR1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5445479 | 0.82 | POLB (0.66) | POLBIDH1NPSR1SMN1; SMN2MAPT | |
| SCHEMBL3052619 | 0.82 | POLB (1.00) | POLBIDH1L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4393909-A1 | HYDANTOIN COMPOUND AND MEDICAL USE THEREOF | Harbin Medisan Pharmaceutical Co., LTD. (CN) | 2024-07-03 | — | — | EP | disclosed |
| US-7160902-B2 | Amide derivatives and methods of their use | ADOLOR CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |
| US-7160902-B2 | Amide derivatives and methods of their use | ADOLOR CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |
| WO-2005049564-A1 | AMIDE DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2005-06-02 | — | — | WO | disclosed |
| US-20050107355-A1 | Amide derivatives and methods of their use | CUBIST PHARMACEUTICALS, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107355-A1 | Amide derivatives and methods of their use | HRH2, SLC10A2, ALPI | POLB 2823/4885IDH1 3777/4885NPSR1 359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.