Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.45 |
| ▸ | MAOB | P27338 | 6/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27737729 | 0.86 | — | — | |
| Benzidine SCHEMBL28915545 | 0.83 | CYP3A4 (0.69) | HRH3CYP3A4TDP1ALDH1A1TP53 | |
| Biphenyl SCHEMBL10333738 | 0.81 | ALDH1A1 (0.64) | CYP3A4TDP1ALDH1A1TP53TAAR1 | |
| Propylamine SCHEMBL28285508 | 0.81 | HRH3 (0.47) | HRH3CYP3A4TDP1ALDH1A1TP53 | |
| Ethylamine SCHEMBL1615923 | 0.78 | — | — | |
| Ethylamine SCHEMBL28583879 | 0.75 | HRH3 (0.50) | HRH3CYP3A4TDP1ALDH1A1TP53 | |
| Hydrazine SCHEMBL4770619 | 0.75 | — | — | |
| SCHEMBL30589936 | 0.74 | ALDH1A1 (0.55) | HRH3CYP3A4TDP1ALDH1A1TP53 | |
| Ethylenediamine SCHEMBL29779726 | 0.74 | — | — | |
| SCHEMBL30135412 | 0.74 | ALDH1A1 (0.55) | HRH3CYP3A4TDP1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032008-A | Method for dyeing keratin materials using at least one blue, violet or green dye and at least one disulfide, thiol or protected thiol fluorescent dye | 莱雅公司 | 2020-04-17 | — | — | CN | claimed |
| US-20070014729-A1 | Tissue engineered scaffolds and mehtods of preparation thereof | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-01-18 | — | — | US | disclosed |