Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 6/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5349848 | 1.00 | MAPK9 (0.44) | MAPK9MAPK8MAPK10MEN1KMT2A | |
| SCHEMBL5337175 | 0.84 | FFAR1 (0.38) | MEN1KMT2AALDH1A1MAPK1P2RX7 | |
| SCHEMBL5337171 | 0.84 | FFAR1 (0.38) | MEN1KMT2AALDH1A1MAPK1P2RX7 | |
| SCHEMBL2828455 | 0.82 | SMN1; SMN2 (0.36) | MEN1KMT2AMAPK1P2RX7CYP1A2 | |
| SCHEMBL2828454 | 0.82 | SMN1; SMN2 (0.36) | MEN1KMT2AMAPK1P2RX7CYP1A2 | |
| SCHEMBL5340343 | 0.78 | CYP1A2 (0.39) | MAPK9MAPK8MAPK10MEN1KMT2A | |
| SCHEMBL5340350 | 0.78 | CYP1A2 (0.39) | MAPK9MAPK8MAPK10MEN1KMT2A | |
| SCHEMBL5342412 | 0.76 | CTBP2 (0.40) | MAPK9MAPK8MEN1KMT2AALDH1A1 | |
| SCHEMBL5342416 | 0.76 | CTBP2 (0.40) | MAPK9MAPK8MEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL5342994 | 0.75 | MAPK8 (0.43) | MAPK9MAPK8MAPK10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070232686-A1 | Cyanoamidine P2X7 Antagonists for the Treatment of Pain | CARROLL WILLIAM A | 2007-10-04 | — | — | US | disclosed |
| US-7241776-B2 | Cyanoamidine P2X7 antagonists for the treatment of pain | ABBOTT LABORATORIES (US) | 2007-07-10 | — | — | US | disclosed |
| US-20060025614-A1 | Cyanoamidine P2X7 antagonists for the treatment of pain | ABBVIE INC. | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025614-A1 | Cyanoamidine P2X7 antagonists for the treatment of pain | P2RX2, P2RX1, P2RX7 | MAPK9 1566/4885MAPK8 1359/4885MAPK10 1081/4885 |
| US-20070232686-A1 | Cyanoamidine P2X7 Antagonists for the Treatment of Pain | P2RX2, P2RX1, P2RX7 | MAPK9 1566/4885MAPK8 1359/4885MAPK10 1081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.