Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 16/20 | 0.46 |
| ▸ | TPO | P07202 | 11/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536693 | 0.92 | MPO (0.53) | MPOTPOOPRM1KCNH2CYP3A4 | |
| SCHEMBL1536612 | 0.91 | MPO (0.53) | MPOTPOOPRM1KCNH2CYP3A4 | |
| SCHEMBL1536648 | 0.78 | MPO (0.52) | MPOTPOOPRM1KCNH2CYP3A4 | |
| SCHEMBL29211255 | 0.76 | MPO (0.52) | MPOTPOOPRM1KCNH2CYP3A4 | |
| SCHEMBL29211289 | 0.74 | MPO (0.48) | MPOTPOOPRM1KCNH2CYP3A4 | |
| SCHEMBL30028986 | 0.71 | MPO (0.59) | MPOTPOOPRM1KCNH2CYP3A4 | |
| SCHEMBL30749182 | 0.70 | MPO (0.68) | MPOTPOKCNH2CYP3A4 | |
| SCHEMBL30029530 | 0.69 | MPO (0.54) | MPOTPOOPRM1KCNH2CYP3A4 | |
| SCHEMBL29211246 | 0.68 | MPO (0.46) | MPOTPOOPRM1KCNH2CYP3A4 | |
| SCHEMBL28896294 | 0.67 | MPO (0.43) | MPOTPOOPRM1KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824855-A1 | NOVEL PYRROLO [3, 2-D]PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THERAPY | AstraZeneca AB (SE) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006062465-A1 | NOVEL PYRROLO [3, 2-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-06-15 | — | — | WO | disclosed |