Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.61 |
| ▸ | HTR2C | P28335 | 5/20 | 0.61 |
| ▸ | HTR2B | P41595 | 5/20 | 0.61 |
| ▸ | HRH2 | P25021 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5354709 | 0.87 | HRH2 (0.64) | HTR2AHTR2CHTR2BHRH2ALDH1A1 | |
| SCHEMBL4054407 | 0.87 | HTR2A (0.47) | HTR2AHTR2CHTR2BHRH2ALDH1A1 | |
| SCHEMBL5350384 | 0.86 | HTR2A (0.57) | HTR2AHTR2CHTR2BHRH2ALDH1A1 | |
| SCHEMBL4054294 | 0.85 | HTR2A (0.49) | HTR2AHTR2CHTR2BHRH2ALDH1A1 | |
| SCHEMBL5344670 | 0.84 | ALDH1A1 (0.49) | HTR2AHTR2CHTR2BHRH2ALDH1A1 | |
| SCHEMBL5347587 | 0.83 | CYP1A2 (0.50) | HTR2AHTR2CHTR2BHRH2ALDH1A1 | |
| SCHEMBL5349348 | 0.83 | HRH2 (0.60) | HTR2AHTR2CHTR2BHRH2SMN1; SMN2 | |
| SCHEMBL14559252 | 0.83 | KDM4E (0.51) | HTR2AHTR2CHTR2BHRH2ALDH1A1 | |
| SCHEMBL5340905 | 0.82 | CNR1 (0.52) | HTR2AHTR2CHTR2BHRH2ALDH1A1 | |
| SCHEMBL5344746 | 0.82 | HRH2 (0.60) | HTR2AHTR2CHTR2BHRH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189741-B2 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents | ALMIRALL PRODESFARMA S.A. (ES) | 2007-03-13 | — | — | US | disclosed |
| EP-1330453-B1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA SA (ES) | 2006-03-29 | — | — | EP | disclosed |
| US-20040116471-A1 | Indolylpiperidine derivatives as antihistaminic aand antiallergic agents | ALMIRALL PRODESFARMA S.A. (ES) | 2004-06-17 | — | — | US | disclosed |
| EP-1330453-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002036589-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA S.A. (ES) | 2002-05-10 | — | — | WO | disclosed |