Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5356815 | 0.87 | HTR6 (0.77) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL1413782 | 0.86 | HTR6 (0.73) | HTR6CYP3A4CYP2D6HTR1ADRD2 | |
| SCHEMBL5698341 | 0.84 | HTR6 (0.80) | HTR6CYP3A4CYP2D6HTR1ADRD2 | |
| SCHEMBL5374506 | 0.84 | HTR6 (0.78) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL946446 | 0.82 | HTR6 (1.00) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL5364773 | 0.82 | HTR6 (0.74) | HTR6CYP3A4CYP2D6HTR2A | |
| SCHEMBL5366543 | 0.80 | HTR6 (1.00) | HTR6CYP3A4CYP2D6HTR1ADRD2 | |
| SCHEMBL4671213 | 0.79 | HTR6 (0.87) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL7974071 | 0.77 | HTR6 (0.62) | HTR6CYP3A4CYP2D6DRD2 | |
| SCHEMBL3337694 | 0.77 | HTR6 (0.63) | HTR6CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007138611-A1 | 3-(HETEROCYCLYL)-N-(ARYLSULFONYL)INDOLE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2007-12-06 | — | — | WO | disclosed |