Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5353560 | 1.00 | ALDH1A1 (1.00) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL3112087 | 0.85 | ALDH1A1 (0.73) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL3112082 | 0.85 | ALDH1A1 (0.73) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL5357917 | 0.80 | ALDH1A1 (0.70) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL23162497 | 0.80 | ALDH1A1 (0.66) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL23162498 | 0.80 | ALDH1A1 (0.66) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL23207060 | 0.80 | ALDH1A1 (0.66) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL5357915 | 0.80 | ALDH1A1 (0.70) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL3017850 | 0.78 | ALDH1A1 (0.64) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL3017848 | 0.78 | ALDH1A1 (0.64) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265134-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-20040192926-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192926-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | ALDH1A1 3104/4885RAB9A 2382/4885SMN1; SMN2 4473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.