Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14532590 | 0.93 | SIGMAR1 (0.48) | GRIN2BSIGMAR1 | |
| SCHEMBL5350307 | 0.93 | SIGMAR1 (0.48) | GRIN2BSIGMAR1 | |
| SCHEMBL14502231 | 0.93 | SIGMAR1 (0.48) | GRIN2BSIGMAR1 | |
| SCHEMBL5350303 | 0.93 | SIGMAR1 (0.48) | GRIN2BSIGMAR1 | |
| SCHEMBL5353035 | 0.91 | GRIN2B (0.45) | GRIN2BSIGMAR1 | |
| SCHEMBL5353451 | 0.89 | GRIN2B (0.57) | GRIN2BSIGMAR1 | |
| SCHEMBL5347058 | 0.87 | GRIN2B (0.56) | GRIN2BSIGMAR1 | |
| SCHEMBL5347607 | 0.85 | GRIN2B (0.50) | GRIN2BSIGMAR1 | |
| SCHEMBL5347603 | 0.85 | GRIN2B (0.50) | GRIN2BSIGMAR1 | |
| SCHEMBL14502229 | 0.85 | GRIN2B (0.50) | GRIN2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217716-B2 | N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists | MERCK & CO., INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-7217716-B2 | N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists | MERCK & CO., INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-7217716-B2 | N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists | MERCK & CO., INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-7053089-B2 | N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists | MERCK & CO., INC. (US) | 2006-05-30 | — | — | US | disclosed |
| EP-1379520-B1 | N-SUBSTITUTED NONARYL-HETEROCYCLIC NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2006-04-26 | — | — | EP | disclosed |