Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533878 | 0.90 | REN (0.54) | RENKCNH2CYP3A4 | |
| SCHEMBL556870 | 0.84 | REN (0.75) | RENKCNH2CYP3A4PTGDR2 | |
| SCHEMBL535144 | 0.83 | REN (0.74) | RENKCNH2CYP3A4MTNR1AMTNR1B | |
| SCHEMBL534449 | 0.81 | REN (0.66) | RENKCNH2CYP3A4PTGDR2 | |
| SCHEMBL556618 | 0.81 | REN (0.75) | RENKCNH2CYP3A4PTGDR2 | |
| SCHEMBL556921 | 0.80 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL556726 | 0.80 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL557684 | 0.80 | REN (0.61) | RENKCNH2CYP3A4MTNR1AMTNR1B | |
| SCHEMBL556463 | 0.79 | REN (0.58) | RENKCNH2CYP3A4MTNR1AMTNR1B | |
| SCHEMBL534057 | 0.78 | REN (0.58) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |