Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31130054 | 0.87 | HTR2C (0.68) | HTR2CHTR2BTSHRCASP1CASP7 | |
| SCHEMBL30555216 | 0.87 | HTR2C (0.61) | HTR2CHTR2BMAPTBRD4 | |
| SCHEMBL1156335 | 0.87 | HTR2C (0.68) | HTR2CHTR2BTSHRCASP1CASP7 | |
| SCHEMBL1155852 | 0.85 | MEN1 (0.55) | SMN1; SMN2HSD17B10HTTMAPTPOLB | |
| SCHEMBL5635199 | 0.84 | GAA (0.54) | HTR2CHTR2BMAPTRAB9A | |
| SCHEMBL15711202 | 0.80 | MAPT (0.64) | HTR2CHTR2BATMCASP1CASP7 | |
| SCHEMBL7024946 | 0.80 | KCNH2 (0.53) | HTR2CTSHRMAPT | |
| SCHEMBL5361852 | 0.80 | TGM2 (0.52) | TSHRSMN1; SMN2 | |
| SCHEMBL1156423 | 0.80 | POLB (0.52) | HTR2CHTR2BMAPTPOLBKDM4E | |
| SCHEMBL2280522 | 0.79 | MEN1 (0.68) | SMN1; SMN2HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-20040220216-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2004-11-04 | — | — | US | disclosed |
| WO-2003037252-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220216-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | HTR2C 4360/4885HTR2B 4480/4885TSHR 1987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.