Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 20/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.55 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | GGT1 | P19440 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11126823 | 0.89 | PTGS2 (0.54) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL942835 | 0.88 | PTGS2 (0.64) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL6203753 | 0.87 | PTGS2 (0.51) | PTGS2ALDH1A1PTGS1HSD17B10 | |
| SCHEMBL6031819 | 0.86 | PTGS2 (0.62) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL9632572 | 0.84 | PTGS2 (0.60) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL6863145 | 0.82 | ELANE (0.47) | PTGS2 | |
| SCHEMBL13402253 | 0.82 | PTGS2 (0.58) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL338196 | 0.82 | PTGS2 (0.68) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL29432883 | 0.82 | PTGS2 (0.68) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL3984466 | 0.82 | SLC6A9 (0.54) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129169-A2 | COX- II INHIBITORS FOR IMPROVING REPRODUCTIVE SUCCESS IN A FEMALE ANIMAL | PFIZER LIMITED (GB) | 2007-11-15 | — | — | WO | disclosed |
| EP-1191929-A4 | (Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS | UNIV TEMPLE (US) | 2005-02-16 | — | — | EP | disclosed |
| US-6656968-B1 | Selectively inhibit the cyclooxygenase activity of COX-2 over COX-1; addition polymers of compound | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-12-02 | — | — | US | disclosed |
| US-6656968-B1 | Selectively inhibit the cyclooxygenase activity of COX-2 over COX-1; addition polymers of compound | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-12-02 | — | — | US | disclosed |
| EP-1191929-A2 | (Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS | Temple University of the Commonwealth System of Higher Education (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077169-A2 | (Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-12-21 | — | — | WO | disclosed |