Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 4/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.39 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5349179 | 0.85 | HRH2 (0.58) | HRH2HTR6ALDH1A1KDM4EHPGD | |
| SCHEMBL5350942 | 0.82 | HTR6 (0.46) | HRH2HTR6SLC5A2HTR2CHTR2A | |
| SCHEMBL4055720 | 0.81 | HRH2 (0.43) | HRH2STAT3TSHRALDH1A1KDM4E | |
| SCHEMBL14280694 | 0.81 | SMO (0.55) | HTR6SMOSLC5A1SLC5A2HTR2C | |
| SCHEMBL5343906 | 0.80 | HTR2A (0.58) | HRH2HTR6SMOSLC5A1SLC5A2 | |
| SCHEMBL5342585 | 0.78 | HRH2 (0.56) | HRH2HTR6SMOSLC5A1SLC5A2 | |
| SCHEMBL8316249 | 0.78 | HTR6 (0.53) | HTR6HTR2CADRB2CAMK2DALDH1A1 | |
| SCHEMBL6781286 | 0.77 | HTR6 (0.52) | HRH2HTR6SMOHTR2CADRB2 | |
| SCHEMBL5344809 | 0.77 | SMO (0.49) | HTR6SMOSLC5A1SLC5A2HTR2C | |
| SCHEMBL5349348 | 0.77 | HRH2 (0.60) | HRH2HTR6HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189741-B2 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents | ALMIRALL PRODESFARMA S.A. (ES) | 2007-03-13 | — | — | US | disclosed |
| EP-1330453-B1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA SA (ES) | 2006-03-29 | — | — | EP | disclosed |
| US-20040116471-A1 | Indolylpiperidine derivatives as antihistaminic aand antiallergic agents | ALMIRALL PRODESFARMA S.A. (ES) | 2004-06-17 | — | — | US | disclosed |
| EP-1330453-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002036589-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA S.A. (ES) | 2002-05-10 | — | — | WO | disclosed |