Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 4/20 | 0.64 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.64 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | GMNN | O75496 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | THPO | P40225 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5369940 | 0.85 | CSNK1D (0.46) | CSNK1DCSNK1A1CSNK1EMAPK1L3MBTL1 | |
| SCHEMBL5361384 | 0.83 | MDM2 (0.54) | ALDH1A1LMNAMAPTMDM2CDK2 | |
| SCHEMBL5376881 | 0.83 | CSNK1D (0.46) | CSNK1DCSNK1A1CSNK1EMAPK1L3MBTL1 | |
| SCHEMBL5368833 | 0.82 | PLK4 (0.60) | ALDH1A1MAPTSMN1; SMN2TDP1RET | |
| SCHEMBL7135678 | 0.82 | NPC1 (0.65) | CSNK1DCSNK1A1CSNK1EMAPK1L3MBTL1 | |
| SCHEMBL5376699 | 0.81 | PLK4 (0.49) | CSNK1DCSNK1A1CSNK1EMAPK1L3MBTL1 | |
| SCHEMBL7138324 | 0.81 | RET (0.50) | L3MBTL1ALDH1A1MAPTHPGDRAB9A | |
| SCHEMBL5368871 | 0.81 | KMT2A (0.53) | L3MBTL1ALDH1A1MAPTMDM2CDK2 | |
| SCHEMBL7138948 | 0.81 | ERBB2 (0.53) | ALDH1A1MAPTTDP1MDM2RET | |
| SCHEMBL6687938 | 0.80 | CSNK1D (0.71) | CSNK1DCSNK1A1CSNK1EMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | CSNK1D 674/4885CSNK1A1 429/4885CSNK1E 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.