Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.78 |
| ▸ | TDO2 | P48775 | 6/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367396 | 0.88 | KDR (1.00) | KDRPKMMEN1KMT2AKDM4E | |
| SCHEMBL5357068 | 0.85 | KDR (0.88) | KDRPKMMEN1KMT2AKDM4E | |
| SCHEMBL5356996 | 0.84 | KDR (0.79) | KDRPKMMEN1KMT2AKDM4E | |
| SCHEMBL5355012 | 0.76 | KDR (1.00) | KDRPKMMEN1KMT2AKDM4E | |
| SCHEMBL19126788 | 0.76 | KDR (0.55) | KDRTDO2PKMRXFP1MEN1 | |
| SCHEMBL30810537 | 0.76 | KDR (0.55) | KDRTDO2PKMRXFP1MEN1 | |
| SCHEMBL5357342 | 0.76 | KDR (0.74) | KDRPKMCHEK1 | |
| SCHEMBL14590416 | 0.74 | KDR (0.88) | KDRPKMMEN1KMT2AKDM4E | |
| SCHEMBL5371286 | 0.73 | KDR (0.79) | KDRMEN1KMT2AKDM4E | |
| SCHEMBL5370747 | 0.73 | KDR (0.67) | KDRTDO2PKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |