Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.67 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5352066 | 0.92 | KDR (0.64) | KDRPKMTDP1KDM4EALDH1A1 | |
| SCHEMBL5355475 | 0.89 | KDR (0.68) | KDRPKMTDP1KDM4EALDH1A1 | |
| SCHEMBL5362580 | 0.84 | KDR (0.70) | KDRPKMTDP1KDM4EALDH1A1 | |
| SCHEMBL5362476 | 0.82 | KDR (0.65) | KDRPKMTDP1KDM4EALDH1A1 | |
| SCHEMBL5367396 | 0.81 | KDR (1.00) | KDRPKMKDM4EALDH1A1MEN1 | |
| SCHEMBL5357068 | 0.79 | KDR (0.88) | KDRPKMTDP1KDM4EALDH1A1 | |
| SCHEMBL14559410 | 0.77 | KDR (0.57) | KDRKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL5359215 | 0.77 | KDR (0.67) | KDRTDP1KDM4EALDH1A1LMNA | |
| SCHEMBL5371327 | 0.76 | SLC6A2 (0.56) | KDRKDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL5367711 | 0.74 | KDR (0.70) | KDRPKMKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |