Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | TPH1 | P17752 | 1/20 | 0.40 |
| ▸ | PCNA | P12004 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL4610453 | 1.00 | SLC7A5 (0.56) | SLC7A5THRBITGB3ITGA2BGSR | |
| Tyrosine SCHEMBL3507740 | 0.95 | SLC7A5 (0.61) | SLC7A5THRBITGB3ITGA2BGSR | |
| Tyrosine SCHEMBL28438814 | 0.95 | SLC7A5 (0.61) | SLC7A5THRBITGB3ITGA2BGSR | |
| Tyrosine SCHEMBL530008 | 0.93 | SLC7A5 (0.65) | SLC7A5THRBITGB3ITGA2BGSR | |
| Tyrosine SCHEMBL1921853 | 0.93 | SLC7A5 (0.65) | SLC7A5THRBITGB3ITGA2BGSR | |
| Tyrosine SCHEMBL1920944 | 0.93 | SLC7A5 (0.65) | SLC7A5THRBITGB3ITGA2BGSR | |
| Tyrosine SCHEMBL3513723 | 0.93 | SLC7A5 (0.65) | SLC7A5THRBITGB3ITGA2BGSR | |
| Tyrosine SCHEMBL1649464 | 0.92 | SLC7A5 (0.57) | SLC7A5THRBITGB3ITGA2BGSR | |
| Tyrosine SCHEMBL1921493 | 0.92 | SLC7A5 (0.57) | SLC7A5THRBITGB3ITGA2BGSR | |
| Tyrosine SCHEMBL26598018 | 0.92 | SLC7A5 (0.57) | SLC7A5THRBITGB3ITGA2BGSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6287564-B1 | IMMUNIZING ANIMAL WITH ANTIGEN; MEASURING ANTIBODY RESPONSE | UNIVERSITY OF GUELPH (CA) | 2001-09-11 | — | — | US | claimed |
| US-7258858-B2 | Method of identifying high immune response animals | UNIVERSITY OF GUELPH (CA) | 2007-08-21 | — | — | US | disclosed |
| US-20020051789-A1 | Method of identifying high immune response animals | UNIVERSITY OF GUELPH (CA) | 2002-05-02 | — | — | US | disclosed |